Partial purification and properties of renal glutaminase.
نویسندگان
چکیده
In 1935, Krebs (1) suggested that there may be several glutaminases. A useful preparation of renal ‘Lglutaminase” was described by Archibald (2) ; Greenstein and Carter (3) demonstrated the existence of two types of glutaminases which were activated by a-keto acids and phosphate, respectively. The mechanism of the a-keto acid-activated glutaminases has been demonstrated by Meister and Tice (4), whereas nothing is known of the enzymatic mechanism or physiological role of the phosphate-activated enzyme in kidney. This paper reports the results of an initial attempt to purify and study the properties of the phosphate-activated glutaminase of kidney.
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عنوان ژورنال:
- The Journal of biological chemistry
دوره 232 1 شماره
صفحات -
تاریخ انتشار 1958